The Jolly Group
Our Research
We aim to understand the cell biology of HIV-1 infection and spread between T cells, focussing on how HIV-1 hijacks the host T cell machinery to most efficiently replicate while evading antiviral defences. Dissecting the molecular details of how these processes work will provide greater insight into HIV-1 pathogenesis and inform future antiviral strategies. We are also working on SARS-CoV-2 virus-host interactions with emphasis on innate immunity.
Our current research focuses on the following main areas:
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Dissecting virus-host interactions that support successful HIV replication in T cells and understanding what makes a T cell permissive for HIV-1.
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Determining how HIV-1 reprograms T cells during infection and the implications for viral persistence and reservoir formation.
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Determining how SARS-CoV-2 VOCs have evolved to better suppress and evade human innate immune sensing and antiviral restriction factors.
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Evaluating antiviral therapeutics and inhibitors.
We have also teamed up with the Towers lab to study SARS-CoV-2 and its interaction with host cells.
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Click the 'Learn More' button to find out about our research:
We are funded by a Wellcome Investigator Award and are also part of the UKRI funded Genotype to Phenotype SARS-CoV-2 COVID19 consortium.
